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The induction of hypoxia and activation of HIF1 induce stemness and initiate EMT and the metastatic process by modulating the expression of pivotal genes like c-MET, CXCR4, and lysyl oxidase (LOX) [205]

Neurological symptoms matter because they can become permanent if the deficiency is prolonged

Ducrest A, Amacker M, Mathieu YD, Cuthbert AP, Trott DA, Newbold RF, Nabholz M, Lingner J (2001) Regulation of human telomerase activity: repression by normal chromosome 3 abolishes nuclear telomerase reverse transcriptase transcripts but does not affect c-Myc activity

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