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Description

La activacin de MC1R promueve la acumulacin de AMPc en los melanocitos, lo que aumenta la actividad de la tirosinasa y acelera la sntesis de melanina

For a few disorders in this chapter, heme pigment rather than melanin explains the presence of the dark color

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[PUBMED Abstract] Long GV, Luke JJ, Khattak MA, et al.: Pembrolizumab versus placebo as adjuvant therapy in resected stage IIB or IIC melanoma (KEYNOTE-716): distant metastasis-free survival results of a multicentre, double-blind, randomised, phase 3 trial