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Furthermore, an increased plasma von Willebrand factor is found in hyperhomocysteinemic subjects bearing premature arterial disease (Freyburger et al, 1997) and, of major relevance, acute methionine loading induced moderate hyperhomocysteinemia results in a significant increase in von Willebrand factor (Constant et al, 1999)

Pharmacology 11 , 151169 (1974) Jones, D.P., Thor, H., Andersson, B., Orrenius, S.: Detoxification reactions in isolated hepatocytes