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Neuroscience 289:36780 Fiorini AC, Scorza CA, de Almeida AC, Fonseca M, Finsterer J, Fonseca FL, Scorza FA (2021) Antiviral activity of Brazilian green propolis extract against sars-cov-2 (Severe acute respiratory syndrome-coronavirus 2) infection: case report and review

Although MIF shares low sequence homology with natural ligands, such as CXC motif chemokine ligand (CXCL8) and SDF-1 (CXCL12), it contains specific motifs that enable receptor binding upon protein folding

These include upregulation of genes linked to the production of ethylene and the synthesis of peptides that bind metals, such as phytochelatins

Damage to mitochondrial DNA results in loss of mitochondrial membrane potential, impairment in the electron transport chain, and drives the immune and inflammatory responses (Liu and Chen, 2017), (Figure 3)