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The TYR gene, involved in melanin biosynthesis in melanocytes, has been significantly associated with vitiligo in the European population.63 The roles of many susceptibility loci remain unknown, highlighting the lack of understanding in the etiopathogenesis of vitiligo, which continues to be a challenge today

CoQ10 Coenzyme Q10 (CoQ10) supports cellular energy production while also functioning as an antioxidant

GTP cyclohydrolysase 1 (GCH1), the rate-limiting enzyme for BH4 synthesis, also functions as a free-radical trapping antioxidant to inhibit ferroptosis (Zhang et al., 2022)

and Sato (134, 135) observed an increase in 3-nitrotyrosine levels (a product of tyrosine nitration) in severe allergic reactions