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10.1016/j.redox.2018.11.017 176 SmithD

They can be produced in the body from superoxide and hydrogen peroxide (via the Haber-Weiss reaction [Koppenol, 2001]) or by hydrogen peroxide reacting with ferrous Fe 2+ ions (via the Fenton reaction [Goldstein et al ., 1993]): against hydroxyl radicals there is no enzymic defence [Sies, 1993]