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Under this proposed policy, we stated CMS could only use the base date AMP to calculate the benchmark period manufacturer price if the base date AMP was associated with a calendar quarter that overlapped with the time period described at 428.202(c)(1) or (2), as applicable for that Part D rebatable drug

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Dennis G, Sherman BT, Hosack D, Yang J, Gao W, Lane HC, Lempicki R: DAVID: Database for Annotation, Visualization, and Integrated Discovery

As weve noted before, the function is dependent on structure, and the string of amino acids must fold into a specific 3-D shape, or conformation, in order to make a functional protein