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For instance, it has been shown that some MB cell lines including DAOY (SHH), ONS-76 (SHH), D458 (Group-3), HD-MB03 (Group-3), CHLA-01-MED (Group-4) and CHLA-01R-MED (Group-4) showed the growth and metastatization features of MB tumors of each subgroup they belong only when they were cultured in a 3D hyaluronic acid hydrogels but not when cultured in conventional conditions as adherent cells (113)

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29 patients received pregabalin at the standard dose of 150 mg three times a day (arm B)