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Systemic ketorolac is contraindicated for use by patients with advanced renal impairment such as renal failure and in patients at risk for renal failure due to hypovolemia (dehydration)

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Sun W, Bao J, Lin W et al (2016) 2-Methoxy-6-acetyl-7-methyljuglone (MAM), a natural naphthoquinone, induces NO-dependent apoptosis and necroptosis by H 2 O 2 -dependent JNK activation in cancer cells