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Vitamin B12 is also involved in homocysteine metabolism and is critical in proper energy metabolism, immune function, and nerve function

Allergic reactions, such as a rash, itching, swelling, or redness, happen due to high vitamin dosage or as a response to the needle coating

According to the Mayo Clinic, daily supplements of 500 micrograms to 1,000 micrograms are often recommended to help older adults maintain adequate B12 levels, especially if they are at risk of deficiency

While preliminary studies and anecdotal evidence are promising, it is still under investigation and not approved for use as a therapy in many countries