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For example, global inhibition of lactate production prevented remyelination in the corpus callosum after experimental demyelination in mice (~3-months-old), while OPC-rich primary cell cultures displayed heightened differentiation when lactate was added to the glucose medium (Ichihara et al., 2017)

Be Cautious With Effective at a Lower Dose A formulation may produce higher blood exposure in a pharmacokinetic study, but that does not automatically establish that a lower dose produces the same clinical result

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