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Pese a la vida media corta en plasma, los efectos biolgicos posteriores persisten en el tejido durante mucho ms tiempo, lo que es coherente con una cascada de sealizacin en lugar de una actividad dosis-respuesta directa

429 Addressing this constraint, the development of a recombinant urate oxidase, rasburicase and pegloticase has shown superior efficacy in rapidly reducing uric acid plasma concentrations compared to allopurinol