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Although cortical inhibitory neurons (INs) are generated mainly in the ganglionic eminences and migrate to the cortex 21,22,23 , recent lineage tracing studies 1,24,25,26,27 and developmental cell atlases 9,12 have demonstrated that human RG also produce cortical-like INs at late stages of neurogenesis that share transcriptional signatures with caudal ganglionic eminence (CGE) and lateral ganglionic eminence derived INs

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Forelimb grip strength was determined by allowing animals to clasp a suspended wire and the time to release was recorded in females [Young ( n = 8), Old Con ( n = 12), and Old mAb ( n = 15)] and males [Young ( n = 8), Old Con ( n = 10), and Old mAb ( n = 9)]

Furthermore, Nrf2 has been shown to modulate other inflammatory signalling pathways, including the mitogen-activated protein kinase (MAPK) and Janus kinase signal transducer and activator of transcription (JAK-STAT) pathways, contributing to its role in regulating inflammation