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The results of another randomized trial in 39 patients with Alzheimers disease suggested that supplementation with fish oil concentrate (high in omega-3 fatty acids) with or without lipoic acid (600 mg/day) for one year could delay the progression in cognitive and functional impairments assessed by the Instrumental Activities of Daily Living (IADL) scoring system compared to placebo (104)

Methods: A single center, retrospective cohort of 58 children was identified: 38 with PALF (25 who recovered (SR) and 13 who underwent LT) and 20 patients who underwent surveillance liver biopsy following LT, whose histologically normal liver tissue is indistinguishable from otherwise healthy liver biopsies

However, decreases in myelin with ageing are not uniform, with regions of the brain that are myelinated earlier in development (such as the primary motor and sensory regions) undergoing white matter decline later [87]

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