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It is extensively recognised that mitochondria have DNA (mtDNA) that encodes 13 key proteins for the assembly and activity of mitochondrial respiratory complexes

However, the small cohort size contributed to underpowered statistical analysis and marked heterogeneity among patients, emphasizing the need for additional CMD trials in expanded cohorts

Moreover, the first global genome-wide epigenetic analysis in VAT 211 from IR and insulin-sensitive (IS) morbidly obese patients identified a novel IR-related gene, the zinc finger protein 714 (ZNF714) exhibited the highest DNA methylation difference, and its methylation levels is lower in IR patient than in IS patient, consistent with increased transcription levels, such studies provide potential epigenetic biomarkers related to IR in addition to novel treatment targets for the prevention and treatment of metabolic disorders

Moreover, the gut microbiota exercises precise control over the patterns of mucosal glycosylation