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They discovered that depleting the iSPNs of TrkB signalling leads to increased striatal dopamine due to an increase in the number of dopaminergic cells in the midbrain dopaminergic areas switching from a low dopamine-producing state to a high dopamine-producing state, resulting in striatal neuron vulnerability and motor dysfunction

Swisher SG , Anderson TM, Wen DR, Stene MA, Cochran AJ, Golub SH, Holmes EC

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Hence, further studies are needed to definitively determine the precise origin of the MUC5B + cell population