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At higher dosages ( 125 g/mL), EGCG exhibits a cytotoxic effect, leading to the death of approximately 30% of J774A.1 cells while simultaneously inducing the production of substantial amounts of lysozyme and IL-1 , which can contribute to the reduction of inflammation [568, 581]

PubMed Sharifnia T, Wawer MJ, Chen T, Huang QY, Weir BA, Sizemore A, Lawlor MA, Goodale A, Cowley GS, Vazquez F, Ott CJ, Francis JM, Sassi S, Cogswell P, Sheppard HE, Zhang T, Gray NS, Clarke PA, Blagg J, Workman P, Sommer J, Hornicek F, Root DE, Hahn WC, Bradner JE, Wong KK, Clemons PA, Lin CY, Kotz JD, Schreiber SL

J Inherit.Metab Dis 2006;29(5):631-636

De La MonteTong SMM (2014) Brain metabolic dysfunction at the core of Alzheimers disease