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However, one study presented conflicting results in mice, reporting a current-dependent increase in the firing rates of L5p following DOI application (2050 nA) (De Gregorio et al., 2021)

Functional expression of two system A glutamine transporter isoforms in rat auditory brainstem neurons

10.1016/j.bbrc.2016.10.086 Biochem Biophys Res Commun

[19] Augmentation [edit] If therapy with antidepressants (such as selective serotonin reuptake inhibitors [SSRIs]) does not fully treat and discontinue [38] the symptoms of major depressive disorder (MDD) (also known as refractory depression or treatment resistant depression [TRD]) [39] then a second augmentation agent is sometimes added to the therapy