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Most people get B12 from food such as meat, fish, eggs, or dairy

Within the last years, it became evident that renal tubular ferroptosis, a modality of regulated necrosis caused by iron-dependent lipid peroxidation [3], is a pathophysiological hallmark of IRI, raising considerable interest in the development of preventive strategies upon solid organ transplantation [4]

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An RNA-seq screen revealed significant up-regulation of Par-4 among 638 up-regulated and 594 down-regulated genes following treatment with the ferroptosis activator RSL3