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The engineered CAR used the scFv regions previously described 42,54 but with the CD8a hinge/TM domains and 4-1BB costimulatory domain

27,28,30 Adjunct therapy with medications such as anti-anxiety drugs, analgesics, sleep aids, anti-emetics, and anti-diarrheal products can also decrease the predominant withdrawal symptoms and decrease discomfort

Chronic kidney disease occurs when a disease or condition causes the kidneys to function poorly and continues to damage them over the course of months or years