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The 4 stages of B12 deficiency can help identify how the disease progresses: Stage 1: Depletion Low stores of B12 with no symptoms

FIGURE 6 3.3.2.2 Carbazole-based DNMTi Based on the crystal structure of mouse DNMT1 in complex with SAH and cytosine (PDB: 4DA4), a new carbazole DNMTi DC-05 ( 30 ) was found by a structure-based drug design