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Under poor nitrogen conditions, they localize to the nucleus and activate nitrogen utilization genes

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Interestingly, organs like the heart and brain may also benefit from stem cell treatments, as there are also other hormones and peptides in bone marrow like osteocalcin which have been shown to enhance memory, brain function, cardiac function, fitness, metabolism, healing, and tissue remodeling after ischemic damage [120-132, 151-161]