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found that children with sepsis, and particularly those who are administered unbalanced crystalloid solutions during resuscitation, demonstrate a loss or deterioration of the EG, and this effect peaks approximately 6 h after the infusion and is often associated with metabolic acidosis and AKI (134)

[1] [5] While GLP-1 receptors have variable distribution in reproductive tissues, the metabolic changes induced by GLP-1 agonists can have downstream effects on the hypothalamic-pituitary-ovarian axis, which governs menstrual function