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Food intake could be significantly increased by each experimental drug (Figure 1b)

In a randomized trial involving SLE patients, significant reduction in NET complexes was observed in individuals with the STAT4 risk allele who received Tofacitinib treatment, while no impact was observed in STAT4 risk allele-negative patients or those in the placebo group (134)

Improves bone strength Hormone decline may cause decreased bone density, increasing the risk of osteoporosis

Upregulation of autophagy-related proteins (including BCL-1, ATG7, ATG5, and LC3-II) in synovial tissues contributes to synovial fibroblast proliferation, resistance to apoptosis, and chronic inflammatory activation