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Iron deposition occurs primarily in hepatocytes and KCs [58, 6063], which together amplify oxidative stress and further promote the activation of hepatic stellate cells (HSCs) through the secretion of pro-inflammatory and pro-fibrotic cytokines [47]

Further research is needed to elucidate the precise mechanisms linking ferroptosis in adipose tissue and diabetes ( Skeletal muscle cells play a pivotal role in insulin sensitivity/resistance, as they are responsible for approximately 80% of total body insulin-stimulated glucose uptake

The occurrence of ovulation appears to rely on the pivotal function of signaling by insulin in the brain and nervous system

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