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Arson isnt too different from how fibroblasts destroy articular cartilage in rheumatoid arthritis (RA)

Strobel, HW (25 December 1986)

More recently, an alternative sensing mechanism for leucine was proposed based on acetyl-CoA, a downstream product in leucine metabolism, hence expanding the spectrum of possible signaling molecules in AA sensing: in this case, acetyl-CoA was shown to signal leucine availability via facilitating RAPTOR acetylation, a modification that led to mTORC1 activation (Son et al., 2019)

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