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This article was last updated in April 2026

When to See a Doctor While mild vitamin B12 deficiency may go unnoticed in the early stages, certain symptoms should not be ignored, especially if they begin to interfere with daily life or worsen over time

Nevertheless, taking vitamin B12 at high doses can cause minor side effects in almost anyone

Three consecutive prolines at positions 35 (Pro-Pro-Pro) and an additional proline at position 8 create local conformational rigidity through the unique angle constraints of pyrrolidine-containing residues