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This naturally occurring copper complex found in human plasma, saliva and various biological fluids has molecular weights ranging from 340-400 Da depending on copper ions binding state and conformational changes

420 Hashimoto et al

To this end, many drugs have been repurposed, including tocilizumab, sarilumab, heparin, chloroquine, ivermectin, sarilumab, chromones ( Most of the effort has been so far devoted to the identification of medications capable to revert the worst and life-threatening complications of COVID-19, namely cytokine storm and hypercoagulation ( This crucial phase of the malady, in analogy with other viral infections and to a widely accepted pharmacological praxis, should be timely treated either with etiotropic drugs (which in COVID-19 case are still lacking) as well as with host-directed agents to manage/prevent the symptoms (Veronese et al., 2020) and nonsteroidal antiinflammatory drugs (NSAIDs)