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The authors showed that further inhibition of MAT2A activity under these conditions disturbed H3K36me3 methylation and inhibited the oncogenic and developmental transcriptional program of the gliomas, extending survival in multiple models of DMG (Sullivan et al., (2021) showed that the major source of folate in the cellular environment in vivo is 5-methyl-THF, which can sustain the folate cycle in vivo instead of folic acid and bypass the efficacy of antifolate therapies such as methotrexate, which inhibit the pathway upstream