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The original nomogram line separating possible toxicity from unlikely toxicity was based on a 4-hour acetaminophen concentration of 200 mcg/mL (green line), but was subsequently modified by moving the line to a 4-hour acetaminophen concentration of 150 mcg/mL (yellow line) to increase the safety margin for treatment decisions

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Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration