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Acknowledgments Authors are thankful to Lei Meng of Hunan University of Chinese Medi-cine for their guidance on the paper, and the financial support provided by Hunan University of Chinese Medicine

While S100A6, a member of the S100 protein family, and PATZ1, a transcriptional regulator, are speculated to play crucial roles in the fibrotic process, their specific functions and interactions in the context of liver fibrosis remain incompletely understood