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Elkhiat and Hossam G

DOI: Received: Accepted: Published: Publisher Name: Springer, Cham Print ISBN: 978-3-031-19369-9 Online ISBN: 978-3-031-19369-9 eBook Packages: Living Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Kim N, Jinks-Robertson S

2-Acetamidophenol upregulates the expression of glutathione synthesis-related genes (such as GCLC, GCLM, GSS) and iron ion transport genes (such as FPN1, FTH), reduces the accumulation of intracellular reactive oxygen species (ROS) and ferrous ions (Fe2+), and enhances the activity of glutathione peroxidase GPX4, thereby inhibiting macrophage phagocytosis of oxidized low-density lipoprotein (ox-LDL) and foam cell formation