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Valproic acid (VPA), a classic HDACi, modulates GSC DNA methylation, activates Wnt/-catenin signaling, and reduces invasiveness, though its synergism with temozolomide remains controversial (Riva et al., 2016

ENS dysfunction, in turn, exacerbates disturbances in intestinal motility, secretion, and immune regulation, creating a vicious cycle that promotes chronicity and treatment resistance

In Turkiye, rapid urbanization results from infrastructure-led development and economic expansion, which continue to reshape urban areas while often prioritizing spatial growth instead of long-term climate resilience and disaster risk reduction (Balaban, 2012)