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[220] Copper (Cu): Copper plays a vital role in eye health, contributing to collagen formation, vascular maintenance, neurotransmitter synthesis (dopamine, norepinephrine, and serotonin), and the structural integrity of ocular tissues

HIF-1 also controls fibroblast IL-33 production, which in turn enhances HIF-1 expression and generates a regulatory cycle that perpetuates RA inflammation (86)