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Given the sex-specific differences in immunological reactions to both vaccination and COVID-19 infection, several sex hormonal therapies entered pre-clinical and clinical studies to treat both men and women using specific medical interventions [293, 299], for example, anti-androgen treatment (Clinical ID: NCT04446429) and progesterone for the treatment of COVID-19 in hospitalized men (Clinical ID: NCT04365127), both completed in 2021 [293]

10.1080/01480545.2017.1289221 7 AlomarS

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In turn, excessive glutamate stimulates its receptors in CNS, leading to their overactivation, thereby triggering excitotoxic neuronal damage, via provoking the generation of ROS, enhancing lipid peroxidation, disrupting calcium homeostasis and aggravating neuroinflammation, ultimately resulting in neuronal death (Mirzakhani et al