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125 ParkL.ZhouP.PitstickR.CaponeC.AnratherJ.NorrisE

555 Allelic variations of the APOE gene may be the greatest genetic risk for AD

Compounds such as resveratrol, curcumin, NAC), omega-3 fatty acids, and quercetin have the potential to inhibit angiogenesis, reduce oxidative damage, modulate inflammatory pathways, and attenuate pain

Future studies should incorporate human iPS cell-derived astrocyte models, precision delivery platforms and multimodal biomarkers to bridge these gaps and accelerate astrocyte-based therapies from mechanistic insight to clinical practice