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Group 1 metabotropic glutamate receptors trigger glutamate-induced intracellular Ca(2+) signals and nitric oxide release in human brain microvascular endothelial cells

We demonstrated that 7OH is a potent low-efficacy agonist at mMOR and hMOR in the efficacy range comparable to buprenorphine ( E max ~ 20% versus DAMGO), in a cell-based assay without signaling amplification (Nb33 BRET assay)