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Enhanced expression of glucose transporter-1 in vascular smooth muscle cells via the Akt/tuberous sclerosis complex subunit 2 (TSC2)/mammalian target of rapamycin (mTOR)/ribosomal S6 protein kinase (S6K) pathway in experimental renal failure

10.3390/nu15061310 195

, IL-1 blocker doesnt stop mtDNA release but stops its effect), whereas some drugs act at the mitochondrial level (like MitoQ stops the ROS that would lead to IL-1 production)

Similarly, one study showed that Tmed4(-/-) mice had endogenous regulatory T (Treg) cells that shifted toward a more inflammatory phenotype with enhanced anti-tumor activity in a colorectal cancer model (84)