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Other IGF-I deficiency conditions Renal diseases As previously stated, the IGF system is involved in normal kidney development, and age-related dysregulation of this system may play a role in kidney and vascular diseases, including hypertension[138]

They were housed under controlled laboratory conditions with a 12h/12 h light/dark cycle, at a constant temperature of 25C 1C and relative humidity of 60% 10%