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MTHFR converts 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, the cofactor form necessary for the re-methylation of homocysteine to methionine (see Figure 2 above)

Under A 2535 stress conditions, EGCG, L-theanine, and EGCG + L-theanine significantly downregulated neurotoxic proteins such as p62, ubiquitination and 4-HNE, and inhibited inflammatory pathways (Figures 3A,B)

In our previous study, we identified a TDC coding gene from Lactobacillus brevis CGMCC 1.2028 and successfully expressed the soluble protein in Escherichia coli BL21(DE3) 10