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Heart disease and stroke statistics-2023 update: a report from the American Heart Association

Influence metabolism indirectly by hormonal means

Dysregulation in mitochondrial sheath formation can result in reduced sperm midpiece flexibility, impaired midpiece structural stability and perturbed energy production, all of which are detrimental for effective sperm motility and overall male fertility

[1] Spike-timing-dependent plasticity (STDP), where a presynaptic neuron firing just milliseconds before a postsynaptic neuron leads to synaptic strengthening (timing-based long-term potentiation LTP), while firing after the postsynaptic neuron causes weakening (timing-based long-term depression LTD)