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Indeed, it is reported that the interior of advanced atheromatous lesions functions as a pro-oxidant environment in which erythrocytes breakdown and release both heme and iron to promote further lipid oxidation, thereby amplifying endothelial cell cytotoxicity (Balla et al., 1991

3.5.1 Experimental and Preclinical Studies In the tumor microenvironment, adipocytes served as a metabolic regulator and an energy provider to promote the survival and growth of several cancer cells

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Oxygen consumption rate (OCR), spare respiratory capacity, and proton leakage were automatically calculated and recorded using the Seahorse XFe24 analyzer (Santa Clara, CA, USA) 22