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NRXN1 knock-out mice models show that -neurexins are crucial for maintaining post-synaptic NMDA-receptor function, regulating synaptic transmission, and organizing the pre-synaptic terminals by coupling Ca 2+ channels on the pre-synaptic surface [50,51,52], accompanied by behavioral abnormalities that resemble the core symptoms of ASD [53]

The most common cause of this condition is due to wear and tear that affects the spine as you age, known as degenerative spondylosis

As seen in Table 1, 73.4% of patients had been using pens for 19 years, 10.6% patients for less than 1 year and 16% for over 9 years

Cellular energy & mitochondrial function studies