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If swallowed, consult a doctor immediately

Magn Reson Med 60:14881497

We did not observe any significant differences between TDP-43 +/+ and TDP-43 K408R/K408R with respect to body weight or motor abilities indicating that blocking TDP-43 SUMOylation does not lead to gross developmental abnormalities (Fig

ii) Utilizing the steric hindrance conferred by dimerization reduces protease access to the active site and significantly improving stability against proteases 49,50