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The following covariates were adjusted in the model: child sex, delivery type, parity, gestational age, birth weight, maternal age, maternal marital status, prenatal smoking, prenatal alcohol use, intrauterine inflammation, preeclampsia, diabetes mellitus, maternal stress, estimated cell-type proportions (CD4 + T cells, CD8 + T cells, B cells, monocytes, granulocytes, natural killer cells and nucleated red blood cells) and surrogate variables

Link Marcuzzo, A

de Boer and H

These findings shed light on mechanisms underlying 5FU resistance and propose a rational strategy for combination therapy in CRC, emphasizing the potential clinical benefit of targeting mitochondrial metabolism to overcome resistance and enhance patient outcomes