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The current standard operating procedure by the European Center for the Validation of Alternative Methods (ECVAM) recommends the use of MTT reduction as parameter to make prediction on the skin irritancy of substances using EpiSkin TM test method, while IL-1 endpoint is regarded as a useful adjunct to MTT assay 48

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It increases blood flow to the follicle and extends the anagen phase

Many findings are encouraging, but no skincare ingredient should be viewed as a guaranteed solution