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Both are studied in tissue repair contexts but via distinct mechanisms

Immunofluorescence findings demonstrated that the conjugation of Lep with liposomes facilitated the docking of human brain microvascular endothelial cells (HBMECs) and SH-SY5Y cells via the Lep receptor, thereby enhancing their ability to permeate the BBB and facilitate cellular uptake

This is in contrast to 51 integrin which ultimately leaves FAs and translocates to fibrillar adhesions (Katz et al., 2000)

Retatrutide is an investigational triple receptor agonist (GLP-1, GIP, glucagon) that remains unlicensed in the UK, with no MHRA approval, no NHS availability, and no BNF listing as of 20242025