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Data and materials availability The raw sequencing data generated in this study have been deposited in the NCBI Sequence Read Archive (SRA) under the BioProject accession number PRJNA1345061.All LC-MS raw data for metabolomics have been uploaded to the Metabolomics Workbench ( with the project ID ST003920 ( All other data are available in the manuscript or supplementary materials

doi: 10.1039/C3FO60400D

This reactive metabolite produces conjugation adducts for many cellular proteins, including those involved in the mitochondrial ETC and others [110, 268, 269]