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doi: 10.1111/pcn.12175 54 ChenKTWuCHTsaiMHWuYCJouMJHuangCCet al

Treatment recommendations are individualized and based on clinical appropriateness rather than a one-size-fits-all approach

2018;13:e0191532 87

Chemical synthesis via SPPS is crucial for these modifications, enabling precise sequence control, improved stability, and exploration of structure-activity relationships ( 4.1 Incorporation of unusual amino acids Chemical synthesis of AMPs offers advantages over natural extraction, enabling precise sequence modification via solid-phase peptide synthesis (Pazgier et al., 2006