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The relationship between B12 and mental health is well established in medical literature, though it is primarily characterised by the psychiatric consequences of deficiency rather than excess

Diabetes 59(4):10301037 Calzetta L, Matera MG, Cazzola M (2018) Pharmacological mechanisms leading to synergy in fixed-dose dual bronchodilator therapy

While these comments are out of scope for this final rule because they are not about the specific proposal that the standard for identification of an overpayment be amended, we appreciate the feedback

Furthermore, ZraP mediated repression of the ZraP-SR system may serve to counteract deleterious effects associated with a sustained stress response, however the chaperone activity of ZraP alone does not protect the cell from envelope stress (Rome et al., 2018)